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Key ones include: Magnesium citrate (200-400 mg daily): Helps prevent constipation, supports sleep quality, and reduces muscle cramps B12 or methylcobalamin: GLP-1 agonists can reduce B12 absorption over time, and some compounded formulations include B12 in the compound for this reason Electrolytes: Sodium, potassium, and magnesium supplementation helps offset the dehydration risk from reduced food intake Protein powder: A practical way to maintain protein targets when appetite makes eating full meals difficult Some compounded formulations include additional ingredients like glycine , niacinamide , or glycine plus B12 combinations

However, they do not yet provide robust longterm comparative outcome data (toxicity, quality of life [QoL], tumor control) sufficient to demonstrate a widened therapeutic window in this indication

Cosmetic use Dix also expressed concern over the shift in use of weight-loss drugs from a medical necessity to 'cosmetic' use, especially by those aspiring to have a 'perfect' body shape

Reasons to implement regular monitoring Once patients are prescribed semaglutide, testing every few months enables healthcare providers, both in-person or through telehealth, to supervise usage and monitor patients for positive or adverse effects