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Direct bonding to the sulfhydryl group of GSH in the cytoplasm has been shown to inactivate cisplatin, for example
Bianchi GP, Marchesini G, Brizi M, Rossi B, Forlani G, Boni P, Melchionda N, Thomaseth K, Pacini G
M.XuW.WalkerB.TrimbleE
Harsh rubbing, especially on the face, can cause irritation and reduce comfort
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