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Moreover, previous clinical and basic studies by the authors have demonstrated that rifaximin can improve gut hyperpermeability and prevent hepatic exposure to endogenous lipopolysaccharide (LPS), which plays a detrimental role in skeletal muscle homeostasis (22,23)

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Animal studies conducted in the Sekhar lab have shown that restoring glutathione levels by providing GlyNAC reverses glutathione deficiency, reduces oxidative stress and fully restores mitochondrial function in aged mice