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While the exact mechanisms remain unclear, several factors are implicated, including nutritional aspects, mechanical unloading, loss of lean mass, and alterations in the secretion of gut hormones and adipokines [8, 10]

Eating too little, skipping protein, ignoring hydration, and stopping medications in the early stages

The result is an "energy crisis." In chronic cases, neurons enter a state of metabolic depression they are dormant, "idling" cells [5]