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Prediction of thyroid C-cell carcinogenicity after chronic administration of GLP1-R agonists in rodents (Toxicology and Applied Pharmacology)

Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

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