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Both medications play critical roles in metabolic regulation, though through entirely different mechanismssemaglutide through incretin pathways and thyroid hormone through nuclear receptor-mediated gene transcription

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Regarding clinical outcomes, hospitalization was the most common outcome (n = 3,336, 11.5%), while death (n = 234, 0.8%) and life-threatening events (n = 354, 1.2%) occurred less frequently

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Diabetes Care 2019;42:227281.PubMed 22

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