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The nuclear factor E2 related to factor 2-antioxidant/heme oxygenase 1 response element (Nrf2-ARE/HO-1), a key metabolic pathway for genetic signaling transduction of enzymes related to the antioxidant system, is impaired in vitiligo patients ( 2 O 2 )
Eligible participants were adults with type 2 diabetes irrespective of background glucose-lowering treatment
Intracellular signaling and secondary pathways MC1R-MC5R receptor activation primarily couples Gs but also recruits, to varying extents depending on the receptor and agonist, other pathways: Gq (phospholipase C, IP3, calcium), Gi under certain conditions (notably MC3R), and the ERK1/2 MAP kinase pathway via arrestin and EGFR transactivation
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