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Presented for research literature review only Orlandi A et al

Although replacement of lost neurons remains difficult, NSCs can release trophic factors and EVs that support synaptic remodeling, remyelination, neurite growth, and local plasticity [29]

To systematically evaluate the pathways driving this sensitivity, we performed continuous gene set enrichment analysis (GSEA) ranking all mapped genes by their Pearson correlation coefficient ( R ) between basal expression (log 2 (TPM + 1)) and the PRISM log 2 (fold de-enrichment) across the 470 matched cell lines (note that 5 cell lines were not listed on HPA and were therefore not included

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