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L., Xi, J
It is conceivable that the design of these studies, mainly the low dose of liraglutide used and the short duration follow-up, failed to clearly separate the direct effect of liraglutide on hyperandrogenism from the weight loss derivative one
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The structural basis for orforglipron's mechanism was published in the Proceedings of the National Academy of Sciences in 2020, revealing through cryo-electron microscopy (cryo-EM) how a small molecule could stabilize the active conformation of a class B GPCR, a finding that fundamentally changed the field's understanding of GPCR pharmacology
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