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In an exploratory analysis of the results of the REWIND trial, a CVOT for dulaglutide (another once-weekly GLP-1RA), a highly significant reduction of 13%-14% was observed in the risk of substantive cognitive impairment, also after adjustment for baseline scores, age ,sex, ethnic origin or education [26]
The most widely prescribed weight loss drugs include semaglutide (Wegovy), tirzepatide (Zepbound), and liraglutide (Saxenda)
We need more data on the long-term effects and other outcomes related to cardiovascular health, particularly in lower-risk individuals
21 FDA (2022)
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