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Smith et al., 2001

2 The immunotherapeutic landscape of osteosarcoma: challenges and resistance mechanisms 2.1 The immunosuppressive TME The osteosarcoma TME is a complex ecosystem comprising malignant cells, stromal cells, immune infiltrates, and ECM components embedded within a mineralized bone scaffold (9, 22)

Additional documented functions include the biosynthesis of vitamins, the metabolism and deconjugation of bile salts, diverse enzymatic activities that contribute to nutrient bioavailability, and the neutralization of dietary or microbial toxins (147)

Identification of genomic alterations in oesophageal squamous cell cancer