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Platinum (II) class antitumor drugs such as cisplatin and oxaliplatin, widely used in cancer chemotherapy, target DNA damage and overall cytotoxicity in tumor cells, resulting in cell death (135)
This leads to increased insulin secretion, suppression of glucagon release, reduced hepatic glucose production, and improved glycemic control
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Starting berberine at lower doses (500 mg daily) before escalating, or using it strategically after GLP-1 tolerance stabilizes, helps minimize overlapping adverse effects
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