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Tirzepatide (Mounjaro, Zepbound) and retatrutide (Retara) are dual and triple agonists, not pure GLP-1 agonists
Achieving efficacy with GLP-1 agonists is no longer the primary challenge
Blood Pressure Changes During GLP-1 Treatment Many patients report elevated heart rate or temporary blood pressure spikes during the first 24 weeks of starting semaglutide, a phenomenon sometimes called 'GLP-1 adjustment.' This occurs because the medication's effect on metabolic rate can temporarily increase sympathetic nervous system activity
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