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Brain endothelial cells regulate glucagon-like peptide 1 entry into the brain via a receptor-mediated process

Although GIP does not interact with pancreatic -cells, it has myriad physiological functions, including enhancing glucose-dependent insulin secretion during the postprandial phase, increasing -cell proliferation, and antiapoptotic and neogenetic effect on the -cells

"Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain." PNAS

Tirzepatide is a dual GLP-1/GIP receptor agonist that slows gastric emptying and reduces appetite, potentially affecting nutritional intake