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Subjects homozygous for this mutation ( MTHFR 677TT genotype) exhibit reduced MTHFR activity and increased risk for a wide variety of cancers (41-43), but the evidence of an association between this polymorphism and cancer is inconsistent, with some reports suggesting a reduction in colorectal cancer risk with the T allele (44)

Understanding that curve is particularly important for a multi-agonist like retatrutide, since its triple pathway activation may produce nonlinear effects that differ from those of single pathway agents

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The most common side effects of semaglutide are gastrointestinal, including abdominal discomfort and nausea