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In liver and kidney cells, some substances (nuclear DNA fragments, mitochondrial DNA (mtDNA), heat-shock proteins, hyaluronic acid, etc.) released together with the damage caused by excessive doses of acetaminophen induce the transcription of proinflammatory cytokines

Conversely, a high intake of saturated fats induces different microbial shifts, including increases in Bacteroides , Bilophila , and anaerobes [172, 173]