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Genetic polymorphisms, which were shown to depend on ethnicity, play a major role in the function of CYPs (especially CYP2D6, CYP2C19, CYP2C9, CYP2B6, CYP3A5, and CYP2A6), and lead to distinct pharmacogenetic phenotypes termed as poor, intermediate, extensive, and ultrarapid metabolizers [14]
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Long-term and short-term animal studies have reported no consistent evidence of organ toxicity or reproductive disruption under controlled laboratory conditions
What to Expect During the Transition You might notice some mild stomach side effects come back during the first few weeks, which is a normal part of adjusting to the new medication
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