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doi: 10.1530/JOE-17-0542 47
GLP-1 medications cause nausea, vomiting, diarrhea, and constipation in a substantial percentage of patients, especially during dose titration
The peptide dissolves readily at pH values achievable with water, and the absence of salts minimizes ionic interactions during initial dissolution
The mechanism may involve downregulating NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome activity and suppressing NLRP3 inflammasome assembly through the TLR4/NF-B signaling pathway
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