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Average Weight Loss in the Orforglipron phase 3 ATTAIN-1 Trial Across the 72-week study period, participants: Lost up to 15% of their body weight at the highest dose At 36 mg: 54.6% lost 10%, 36.0% lost 15%, 18.4% lost 20% body weight (all higher than placebo)

The sweetenerbacteria interactions were tested in two independent experiments, whereby the interactions meeting significance thresholds ( P 90% overlap, 30 out of 33 interactions, Appendix Figs

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Temporal and subgroup disparities in mediation effects on cardiovascular outcomes with liraglutide and semaglutide: post-hoc analysis of LEADER and SUSTAIN-6