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GLP-1 signaling may improve mitochondrial biogenesis via PGC-1a/nuclear respiratory factor-1/mitochondrial transcription factor A signaling regulated by adiponectin/ adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK) 49 and elevates the expression of NAD-dependent protein deacetylase sirtuin 1 (SIRT1), which increases the expression of Parkin, leading to mitophagy activation
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Br J Pharmacol (2012) 167:152032.10.1111/j.1476-5381.2012.02105.x 35 DasguptaCZhangL
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