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Well, this is certainly not to say that the drug will never be approved

(9) Labunets IF, Butenko GM, Khavinson VKh, Magdich LV, et al (2003) (Regulating effect of pineal gland peptides on development of T-lymphocytes in CBA aging mice: role of microenvironment of immune system organs and neuroendocrine factors)

The ssGSEA R package was used to calculate four metabolic mode scores of each patient in indicated datasets based on corresponding metabolic gene-sets (Glycolysis, oxidative phosphorylation, fatty acid, and glutamine metabolism) downloaded from Gene Set Enrichment Analysis website (GSEA, (Supplementary Data 1)

Bypass pathway activation engages alternative drivers, including MET, AXL or HER2 amplification, as well as RAS/MAPK or PI3K mutations