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Glutathione (GSH) and GSH biosynthesis pathway proteins such as solute carrier family 7 member 11 (SLC7A11) and glutathione-glutathione peroxidase 4 (GPX4) can convert lipid peroxides to lipid alcohols, which suppress intracellular iron-induced lipid ROS (67)

For instance, It was demonstrated that circadian disruption induced by jet lag or shifted light cycles not only accelerates tumor development but also disrupts endocrine, metabolic, and immune pathways that are central to breast carcinogenesis 40,56

In contrast, excessive Se intake or environmental exposure was associated with an increased risk for type 2 diabetes, neurodegenerative diseases (amyotrophic lateral sclerosis and Parkinsons disease), and increased risk and mortality from some malignancies (carcinoma of prostate, buccal cavity, pharynx, stomach, colon, rectum, lungs, kidney, and urinary bladder, melanoma, multiple myeloma, lymphoid neoplasms, etc.) (43, 49, 50)

Cells can convert it back to its reduced, active form, but this cycle can be compromised if the body is under stress or if the demand for antioxidant activity is high