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3.5 HSP transcription, translation, and the molecular chaperone activation phase As the transcription and translation of HSP genes are activated under the guidance of HSF1, the cell enters the molecular chaperone activity phase (Figure 2c) (Rosenzweig et al., 2019)

NF-kappaB and Rel proteins: evolutionarily conserved mediators of immune responses

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Another limitation is that the pharmacokinetic assessments on the 10th day of dosing in the current trials do not fully reflect the steady-state situation achieved with continuous once-daily dosing in the clinical setting because of the long half-life of approximately 1 week for oral semaglutide