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These data could also be used in future studies to improve the kinetics of our sensor by engineering the HT binding pocket, and more generally to design fluorogenic dyes or other robust, targeted sensors

Consistent with our observations in yeast, the difference in NADPH occupancy suggested a close match of the response ranges of both sensor variants with the physiological NADPH:NADP + ratio (Supplementary Fig

Ontaneda D, Hyland M, Cohen JA (2012) Multiple sclerosis: new insights in pathogenesis and novel therapeutics