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Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease
CntA/B is a notoriously hard enzyme to study, but once it was stabilized, we were able to gain insight into how CntA perceives its L-carnitine substrate with a 3D crystal structure model, and by studying the complete electron transfer pathway, we could see how the protein is able to turn over TMA
They produce weight loss (versus weight gain with insulin), have lower hypoglycemia risk, and have proven cardiovascular benefits that insulin lacks
That is why each ladder step lasts at least 4 weeks the body needs that time to fully adjust
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