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Despite being discovered first, it received less clinical attention for decades because early research suggested that GIP signaling was impaired in type 2 diabetes, making it seem like an unlikely therapeutic target
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Paradoxically, this increase has been associated with improved all-cause mortality as well as cardiovascular mortality, according to a post hoc analysis of the PROactive trial (259)
Manufacturing and API Supply as Strategic Barriers The sheer complexity of manufacturing GLP-1 and GIP peptides at a global scale serves as a practical, non-legal barrier to competition
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