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[12] Beyond that specific episode, GH secretagogues generally can affect glucose metabolism and insulin sensitivity: raising GH tends to oppose insulin action, and studies of oral ghrelin-mimetic secretagogues in older adults have documented measurable effects on glucose handling alongside their GH and IGF-I elevation
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By week 48 (approximately one year), participants lost more than 24% of their starting weightan average of about 58 pounds.[4] This level of weight loss appears greater than what has been observed in studies of medications like Wegovy or Ozempic.[6,7] Additionally, nearly all 338 participants who took lower doses of retatrutide experienced weight reductions between 5% and 15%.[4] Even modest weight loss can have meaningful health benefits
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