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The bioactive natural product T1 , bis(4-hydroxybenzyl)sulfide, with the most striking inhibitory potency against tyrosinase, was chosen as the target compound to characterize its biological effects in tyrosinase inhibition, cell viability, in vitro and in vivo melanin biosynthesis and acute oral toxicity in mice
Similarly, studies on oxidative stress in skin conditions support the idea that antioxidants could play a beneficial role in preserving cellular integrity (Bickers & Athar, 2006)
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