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However, oxidative stress and associated decreases in levels of glutathione (GSH) are known to play a central role in ALD

The dosage and frequency of OHCbl is titrated in each patient to the minimum effective dose in order to account for the painful injections

Owing to its continuous nature, CKRT is not associated with major fluid or osmotic shifts and therefore has a reduced likelihood of aggravating the raised intracranial pressure associated with hyperammonaemia 40

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