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References (Scientific Literature) PMCID: PMC2249747 (1) PMCID: PMC8078644 PMCID: PMC7462336 PMID: 23631796 PMID: 11056412 PMID: 10575337

NNMT uses up nicotinamide by tagging it with a methyl group (a process called methylation) and sending it out as waste

Inhibition of the Trx system by auranofin induced cell death (most likely ferroptosis) only in non-endocrine small cell lung cancer, whereas inhibition of the Grx system by buthionine sulfoximine killed specifically the endocrine cells [203]

5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD