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In melanoma, downregulation of IGF-1 reduces the dry character of melanoma initiating cells, including the expression of dry markers (SOX2, Oct-3/4, CD24 and CD133) and functional properties (melanosphere formation, aldehyde dehydrogenase activity and side population) and eventually inhibiting the proliferation and metastasis of tumor cells (26)
Our metabolic analyses showed that Gclc deficiency led to an accumulation of succinate, indicating a block in the TCA cycle
doi:10.1007/s11419-017-0379-4
GPRC6A is highly expressed in GLUTag cells, and its activation by L-ornithine has shown to induce GLP-1 secretion (102)
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