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In the NTS, PrLH mRNA expression was downregulated exclusively by weight loss caused by food restriction, as shown previously (59, 60)
*In a 68-week clinical study of branded Semaglutide 2.4 mg with lifestyle intervention, mean body weight change was 14.9%
For the full titration schedule and when to increase your dose, see our [semaglutide dosing schedule guide](/guides/semaglutide-dosing-schedule-week-by-week-guide)
It is recommended to consume one vial daily continuously (for a maximum of 3 months) to achieve the best results, in conjunction with a healthy and balanced diet.
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