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In B7H3targeting ADCs armed with a PBD payload that disrupts replication forks, loss-of-function alterations in RB1 and TP53which promote replication stresshave been identified as predictors of therapeutic response 252
This "protective envelope" allows the glutathione to bypass the destructive digestive process and be absorbed more directly into the cells
Shu C, Zhang W, Zhang Y, Li Y, Xu X, Zhou Y, et al
In the original 2017 mouse study, FOXO4-DRI was reported as well-tolerated in vivo at the dosing used
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