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Organophosphorus flame retardants and their metabolites in paired human blood and urine

By binding to GLP-1 receptors, this peptide suppresses appetite, slows gastric emptying, and enhances insulin secretion

These results follow similar findings from the companys ATTAIN-1 trial released earlier this month, which tested the drug on people who were overweight or obese without type 2 diabetes (in general, people without diabetes tend to lose more weight from GLP-1 therapy than those with diabetes)

Importantly, however, the participants in the PIONEER phase 3 trials were not administering a DPP-4i at the start [20,21,22]