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Bhm M, Butler J, Coats A, Lauder L, Mahfoud F, Filippatos G, Ferreira JP, Pocock SJ, Brueckmann M, Hauske SJ, Schueler E, Wanner C, Verma S, Zannad F, Packer M, Anker SD
In 1987, the National Institute of Diabetes and Digestive and Kidney Diseases developed the first criteria for the diagnosis of IC
Consequently, the metabolic pathways initiated by G proteins within GLP-1R involve cAMP activation, extracellular signal-regulated kinases 1 and 2 (ERK 1/2) and increased intracellular calcium levels (17, 19)
Individual timelines vary based on starting weight, dose escalation rate, and overall metabolic response
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