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Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes
To help overcome this, the researchers performed a subgroup analysis of specific characteristics shared by individuals within the pooled studies
The TRIUMPH-4 Phase 3 trial confirmed this: at 68 weeks, mean weight loss had reached 28.7% at 12 mg, an additional 4.5 percentage points beyond the 48-week Phase 2 result
A resting heart rate consistently above 100 beats per minute warrants medical evaluation
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