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A simple decision framework Lexapro is often a reasonable starting point when: Anxiety is prominent Depression and anxiety are mixed together You want a medication that often feels calmer A first-line option for adult depression is the main goal Prozac is often a reasonable starting point when: Fatigue, lethargy, or hypersomnia are central You need broader FDA-approved coverage OCD, panic, or bulimia are part of the picture You want a medication that is more forgiving if a dose is missed In practice, I also look at the texture of the symptoms

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PubMed Pairs well with Glycerin Propylene Glycol Amino Acids (Glycine, Alanine, Proline) Xanthan Gum Panthenol Niacinamide Ceramides Lactic Acid Avoid combining with High concentrations of alcohol (may cause osmotic dehydration) Strong chemical exfoliants at high pH (may impair hyaluronic acid stability) BDDE cross-linked derivatives in certain formulations (safety considerations)