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Metformin versus Ozempic Ozempic, a form of semaglutide, is a once-weekly subcutaneous injection typically administered in the upper arm, thigh, or stomach on a rotating schedule

Underlying mechanisms contributing to cardiovascular and renal protection are at least partially different between GLP-1RAs (mainly anti-atherogenic and vascular effects) and SGLT2is (mainly systemic and intrarenal hemodynamic changes)