tirzepatide surpass trials SURPASS-5: lowers HbA1c in adults with type 2 diabetes on insulin glargine Overview of the SURPASS clinical

Timing: Can be taken with or between meals

Good options include: Chicken, turkey, and lean red meat Fish, particularly oily fish like salmon, mackerel, and sardines (also good sources of omega-3, which may help reduce inflammation) Eggs Greek yoghurt (if you tolerate dairy) Tofu and tempeh Lentils and chickpeas Foods that support insulin sensitivity Choosing foods that release energy slowly helps avoid the blood sugar spikes that worsen insulin resistance: Non-starchy vegetables: leafy greens, broccoli, courgettes, peppers, aubergines, tomatoes Complex carbohydrates: sweet potatoes, oats, quinoa, basmati rice, sourdough bread Healthy fats: avocado, olive oil, nuts, and seeds (walnuts and flaxseeds are particularly good sources of omega-3) High-fibre foods: beans, lentils, vegetables, and berries, which slow the absorption of sugar into the bloodstream Anti-inflammatory foods Chronic low-grade inflammation is a feature of PCOS, and while our overall diet and lifestyle will have a greater influence on managing inflammation than any single food, including foods with anti-inflammatory properties, may help: Oily fish (salmon, mackerel, sardines) at least twice a week Nuts and seeds, especially walnuts, almonds, and flaxseeds Berries, cherries, and pomegranates Leafy greens and cruciferous vegetables (broccoli, kale, spinach) Extra virgin olive oil Turmeric and ginger Foods to limit Some foods may worsen both insulin resistance and Wegovy side effects: Refined carbohydrates and added sugars (white bread, sugary cereals, pastries, sweets) Sugary drinks, including fruit juice Ultra-processed foods and takeaways Excessive caffeine can worsen anxiety, which is common in PCOS Alcohol (affects blood sugar regulation and can worsen nausea from Wegovy) Managing nausea from Wegovy If nausea is an issue, particularly during dose escalation: Eat smaller, more frequent meals rather than large portions Avoid lying down immediately after eating Choose easily digestible foods during the first few weeks (scrambled eggs, white fish, mashed potatoes, cooked vegetables) Ginger tea or ginger supplements may help settle your stomach Physical activity Regular exercise improves insulin sensitivity independently of weight loss, which is particularly beneficial for PCOS

Moving my body and intentionally eating a balanced diet is not only a requirement to get the best weight loss benefits out of a GLP-1, but it has also made me feel that much more excited to continue on this path to a healthier me

We monitor for any nutrient deficiencies that may arise from changes in eating habits, including vitamin B12, calcium, and iron