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Normally, when you eat, GLP-1 is released naturally and has the following actions: Signals the stomach to release food slowly Stimulates the pancreas to stop releasing glucagon, and start releasing insulin to prepare for a spike in blood sugar (Eventually) travels to the brain and acts on several areas involved in appetite regulation, shutting down the desire for food These are powerful effects, but they are tempered by the fact that GLP-1 doesnt stick around for very long
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The other invites a lecture about eating less and moving more
In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]
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