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The phase 2 Exenatide PD2 trial reported a 3.5-point improvement on the Movement Disorder Society Unified Parkinsons Disease Rating Scale part III (MDS UPDRS Part III), and the benefit lasted through a 12-week washout, which suggested possible disease modification
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The EVOKE result is consistent with this logic: semaglutide is a large, acylated molecule with poor brain penetrance, and it did not show benefit in Alzheimers disease
Figure 1 Fatty acid metabolism encompasses long-chain, medium-chain, and short-chain fatty acid processing, with carnitine playing an indispensable role in long-chain fatty acid catabolism
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