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More importantly, the downregulation of the EZH2 gene leads to a decrease in LAT1 ( SLC7A5 ) expression, and, in turn, the downregulation of LAT1 ( SLC7A5 ) or the depletion of essential amino acids can also induce a decrease in EZH2 expression (Dann et al., 2015)

HIC has been used to determine the drug distribution of several ADCs containing auristatin drugs conjugated to inter-chain cysteines (mAb) and engineered cysteines (THIOMAB) through cleavable and noncleavable linkers 4,9-12

doi: 10.1016/j.ccc.2022.07.006 [PubMed] 36807987 Trinka E

Concurrent quantification of oxidized and reduced glutathione and cysteine by targeted mass spectrometry: Applications to ocular tissue biology