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Furthermore, we found that the mRNA expression level of occludin increased, which may be related to a compensatory effect

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Front Pharmacol 9:1535 Dodd J, Jordan R, Makhlina M, Barnett K, Roffel A, Spana C et al (2023) A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans