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To exemplify, aripiprazole and risperidone have proven useful for controlling irritability, aggression and emotional dysregulation, compared to placebo (Salazar, et al., 2023)

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Although the purpose of the study was not to conduct quantitative analyses, questionnaire data showed a trend towards reduction in PHQ-9, GAD-7 and EDE-Q scores (Table 1), which were clinically significant given that change scores of 5, 4 and 0.57 are considered the minimal clinically important differences in PHQ-9, GAD-7 and total EDE-Q scores respectively [38,39,40]