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Both tirzepatide (Mounjaro) and semaglutide (Wegovy) are weekly injections, and after each dose the medication level in your bloodstream rises over the following 24 to 48 hours before gradually plateauing
Notably, these effects were not mimicked by E alone, which failed to rescue cycle perturbations and had a discernible uterotrophic action, but were replicated, in terms of reversal of irregularities of the ovarian cycle, by GLP1 alone, which nonetheless did not elevate LH levels
Additionally, Wegovy commonly causes gastrointestinal side effects such as nausea, vomiting, diarrhoea, and constipation, which affect a substantial proportion of users according to the SmPC
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