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Nat Rev Mol Cell Biol 26(2):123146 Zhao L, Sumberaz P (2020) Mitochondrial DNA damage: prevalence, biological consequence, and emerging pathways
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CJC-1295 and Somatotroph Biology The GHRH-receptor signalling pathway activated by CJC-1295 stimulates adenylate cyclase, increasing intracellular cAMP and engaging PKA-linked transcriptional regulation of the GH gene in somatotroph cells with in vivo research confirming increased pituitary RNA, GH mRNA, and somatotroph cell number following administration, establishing that GHRH-class secretagogues act on multiple levels of GH axis biology beyond simple acute secretion
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