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reported that the expression levels of ALDH2 decreased in mice after long-term alcohol intake, leading to the accumulation of toxic aldehydes and accelerating liver inflammation and fibrosis (Gao et al., 2019b)

Full publication of combination-therapy data is awaited, however interim analysis from the phase II COURAGE trial (NCT06299098) found 3.3% reduction in lean mass of obese patients treated with the combination of trevogrumab and semaglutide, compared with 6.5% reduction with semaglutide alone [70]

Others may reduce dose, change frequency, consider microdosing when appropriate, or transition off medication with closer follow-up

These advancements are exciting, but the drugs are not designed for everyone