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Smith MG, Snyder M (2006) Yeast as a model for human disease

In research contexts, nasal delivery is examined for its ability to: Support rapid compound uptake in controlled models Bypass gastrointestinal degradation pathways Enable precise, repeatable exposure during investigational protocols Facilitate localized signaling studies involving neurological and vascular pathways This delivery format is intended strictly for research methodology evaluation and does not imply suitability for human or clinical use

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In the overall STEP program, nearly 10% of participants without diabetes and more than 30% of participants with type 2 diabetes experienced less than 5% weight loss, despite use of a potent GLP-1 receptor agonist plus lifestyle intervention