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Certain plant-derived polysaccharides (e.g., from Astragalus or Ganoderma lucidum ) promote DNA demethylation of tumor suppressor genes via TET enzymes, inhibit oncogenic histone-modifying enzymes, and regulate cancer-related microRNAs (140)
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Although predominately induced in macrophages, under appropriate stimulation conditions many other cell types will express the iNOS gene
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