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Kovacik A, Kopecna M, Vavrova K
[16] revealed that Curculigo orchioides Gaertn can prevent bone loss by alleviating oxidative stress damage to osteoblast and can also inhibit osteoclast formation, reduce osteoclast genesis and enhances the activity of osteoblast[16, 99]
However, the exact nature of these benefits will depend on how it is applied
The pKa, of imidazole rings varies according to the microenvironment that protein folds in, and this huge pKa fluctuation enables the proteins histidine binding with metals (Miyagi and Nakazawa, 2024)
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